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Genetics & Genomics
DNA sequencing, CRISPR edits, population genetics, and trait mapping.
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RNA-Seq Analysis: From Reads to Differential Expression
7+ hour, 8+ min ago (114+ words) BAM file in genome coordinates Slower; hours per sample at standard settings Fast; minutes per sample Novel splice junction detection A decision framework for choosing a normalization method in RNA-seq analysis: Testing 20,000 or more genes simultaneously at a nominal p-value…...
A practical guide to studying genome function using single-molecule genomics - Nature Reviews Molecular Cell Biology
45+ min ago (1599+ words) Nature Reviews Molecular Cell Biology (2026) Cite this article Krebs, A. R. Studying transcription factor function in the genome at molecular resolution. Trends Genet. 37, 798–806 (2021). Delamarre, A. et al. Chromatin architecture mapping by multiplex proximity tagging. Mol. Cell 85, 2796–2811.e5 (2025). Zheng, M. et al. Multiplex chromatin…...
Israeli Scientists Reveal Directed Drift in Evolutionary Processes
8+ hour, 51+ min ago (298+ words) Israeli Scientists Reveal Evolution May Follow More Predictable Paths Than Previously Thought inkorr.com Israeli Scientists Reveal Evolution May Follow More Predictable Paths Than Previously Thought Directed Drift Shapes Evolutionary Paths According to НВ — Техно: A team of international researchers…...
One Slide, a Hundred Proteins: Molecular Pathology's Leap into the Clinic | Expert’s Interview
12+ hour, 1+ min ago (327+ words) Two of those speakers took on the field’s central question: as molecular pathology shifts from a “research tool” to a “clinical necessity,” how can China chart a path of its own? Professor Ouyang Nengtai of Sun Yat-sen Memorial Hospital and…...
Study reveals unexpected way BRD4 binds to chromosomes
4+ hour, 53+ min ago (188+ words) Study reveals an unexpected way BRD4 binds to chromosomes UA.NEWS Study reveals an unexpected way BRD4 binds to chromosomes Penn State scientists have presented a three-dimensional structure of the cancer-linked protein BRD4 in a complex with its cellular partner. As reported by…...
Seven Students, One Summer, and a New Front in the War on Superbugs
6+ hour, 14+ min ago (946+ words) The Martin Institute for Public Good This summer, a team of seven students joined their professor on the front lines of the high-stakes battle between antibiotics and bacteria. “There are two things we can do about it,” Biology Professor Bryan…...
Correlation vs. Causation: What They Actually Mean
4+ hour, 51+ min ago (778+ words) " Correlation isn't causation" is one of the most repeated phrases in data science and one of the least explained. Here's what each term actually means, why the confusion happens, and four specific ways it goes wrong in practice. If you've…...
AI-assisted design of novel CRISPR/Cas gene editing tools: Hype vs reality
19+ hour, 54+ min ago (1192+ words) News and comment on genetically modified foods and their associated pesticides For many years GMWatch has made the science-based case that the process of CRISPR/Cas gene editing is neither precise in operation nor predictable in outcome. In doing so,…...
The Physics of Lying Down: Where Solace Ends and the Shadows Begin
11+ hour, 6+ min ago (1495+ words) We lie down to escape the weight of a noisy, exhausting world. But sometimes the place that gives us rest slowly becomes the place that keeps us stuck. What does it take to find the strength to stand? There is…...
DNA tech offers both data storage and computing functions
1+ day, 9+ hour ago (307+ words) Researchers from North Carolina State University and Johns Hopkins University have demonstrated a technology capable of a suite of data storage and computing functions -- repeatedly storing, retrieving, computing, erasing or rewriting data -- that uses DNA rather than conventional electronics. Previous…...